منابع مشابه
Decrease of prostaglandin E2 receptor binding is accompanied by reduced antilipolytic effects of prostaglandin E2 in isolated rat adipocytes.
The effect of treatment of isolated rat adipocytes with prostaglandin E2 (PGE2) on subsequent [3H]PGE2 binding was studied. In addition, the antilipolytic effects of was studied. In addition, the antilipolytic effects of PGE2, adenosine, and insulin were studied in control and PGE2-treated adipocytes. Treatment of adipocytes with PGE2 (1 microM) decreased the binding of [3H]PGE2 by 61% (from 11...
متن کاملPleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function.
Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E(2) in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, surv...
متن کاملAntihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
Clinical use of prostaglandin synthase-inhibiting NSAIDs is associated with the development of hypertension; however, the cardiovascular effects of antagonists for individual prostaglandin receptors remain uncharacterized. The present studies were aimed at elucidating the role of prostaglandin E2 (PGE2) E-prostanoid receptor subtype 1 (EP1) in regulating blood pressure. Oral administration of t...
متن کاملCharacterizing the Effects of Prostaglandin E2 on Tendon Mechanical Properties
Elyse Jeannette Baum Characterizing the Effects of Prostaglandin E 2 on Tendon Mechanical Properties (Under the direction of Paul Weinhold) Tendinopathy is a common clinical problem, both athletically and occupationally. It develops from repetitive mechanical loading of tendon; however the molecular mechanisms are not well understood. It is thought that prostaglandin E 2 (PGE 2) and matrix meta...
متن کاملCurcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
Prostaglandin E(2) (PGE(2)) plays a crucial role in the apparent link between tumor growth and chronic inflammation. Cyclooxygenase (COX)-2 and microsomal PGE(2) synthase-1, which are overexpressed in many cancers, are functionally coupled and thus produce massive PGE(2) in various tumors. Curcumin, a polyphenolic beta-diketone from tumeric with anti-carcinogenic and anti-inflammatory activitie...
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ژورنال
عنوان ژورنال: Obstetric Anesthesia Digest
سال: 1989
ISSN: 0275-665X
DOI: 10.1097/00132582-198910000-00063